| Reaction Details |
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 | Report a problem with these data |
| Target | Urease subunit beta |
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| Ligand | BDBM50534776 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1929327 (CHEMBL4432503) |
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| Ki | 3259±n/a nM |
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| Citation |  Macegoniuk, K; Grela, E; Palus, J; Rudzi?ska-Szostak, E; Grabowiecka, A; Biernat, M; Berlicki, ? 1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease Inhibitors. J Med Chem59:8125-33 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urease subunit beta |
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| Name: | Urease subunit beta |
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| Synonyms: | 3.5.1.5 | URE1_HELPY | Urea amidohydrolase subunit beta | Urease subunit beta | hpuB | ureB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61676.43 |
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| Organism: | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
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| Description: | ChEMBL_117195 |
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| Residue: | 569 |
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| Sequence: | MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNN
PSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEA
LAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLK
WMLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADK
YDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPAST
NPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITS
SDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGIS
EYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFA
HHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNP
ETYHVFVDGKEVTSKPANKVSLAQLFSIF
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| BDBM50534776 |
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| n/a |
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| Name | BDBM50534776 |
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| Synonyms: | CHEMBL4539240 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H28N2O4Se2 |
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| Mol. Mass. | 542.39 |
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| SMILES | [#6]-[#6]-[#6](-[#6]-[#8])-[#7]-[#6](=O)-c1ccccc1[Se;v2][Se;v2]c1ccccc1-[#6](=O)-[#7]-[#6](-[#6]-[#6])-[#6]-[#8] |
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| Structure | 
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