| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain testis-specific protein |
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| Ligand | BDBM50260093 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1929409 (CHEMBL4432585) |
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| Ki | 100±n/a nM |
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| Citation |  Bradbury, RH; Callis, R; Carr, GR; Chen, H; Clark, E; Feron, L; Glossop, S; Graham, MA; Hattersley, M; Jones, C; Lamont, SG; Ouvry, G; Patel, A; Patel, J; Rabow, AA; Roberts, CA; Stokes, S; Stratton, N; Walker, GE; Ward, L; Whalley, D; Whittaker, D; Wrigley, G; Waring, MJ Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153). J Med Chem59:7801-17 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain testis-specific protein |
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| Name: | Bromodomain testis-specific protein |
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| Synonyms: | BRDT | BRDT_HUMAN | Bromodomain and extra-terminal motif (BET) | CT9 | Cancer/testis antigen 9 | RING3-like protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 107982.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1502985 |
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| Residue: | 947 |
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| Sequence: | MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVK
LQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQ
ALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSV
FPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSV
ALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVD
VNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVT
MARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERV
KRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRL
KEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSR
EPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQ
ELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSS
DSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECIPPEGRTGVTQIGYCVQDTTSANTTL
VHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGD
SDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKA
RTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQD
KSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD
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| BDBM50260093 |
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| n/a |
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| Name | BDBM50260093 |
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| Synonyms: | CHEMBL4078100 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H33N7O3 |
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| Mol. Mass. | 479.5746 |
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| SMILES | COc1nnc2ccc(nn12)N1CCC(CC1)c1ccc(OCCN2CCN(C)C(=O)[C@H]2C)cc1 |r| |
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| Structure | 
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