Reaction Details |
| Report a problem with these data |
Target | Prostaglandin G/H synthase 1 |
---|
Ligand | BDBM50090628 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_158586 |
---|
IC50 | 7200±n/a nM |
---|
Citation | Bosch, J; Roca, T; Catena, JL; Llorens, O; Pérez, JJ; Lagunas, C; Fernández, AG; Miquel, I; Fernández-Serrat, A; Farrerons, C Synthesis and biological evaluation of 1,3,4-triaryl-3-pyrrolin-2-ones, a new class of selective cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett10:1745-8 (2000) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Prostaglandin G/H synthase 1 |
---|
Name: | Prostaglandin G/H synthase 1 |
Synonyms: | COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_HUMAN | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase) |
Type: | Enzyme |
Mol. Mass.: | 68692.62 |
Organism: | Homo sapiens (Human) |
Description: | P23219 |
Residue: | 599 |
Sequence: | MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
|
|
|
BDBM50090628 |
---|
n/a |
---|
Name | BDBM50090628 |
Synonyms: | 3-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-1-(4-trifluoromethyl-phenyl)-1,5-dihydro-pyrrol-2-one | CHEMBL49011 |
Type | Small organic molecule |
Emp. Form. | C24H17F4NO3S |
Mol. Mass. | 475.455 |
SMILES | CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)N(C1)c1ccc(cc1)C(F)(F)F)c1ccc(F)cc1 |t:11| |
Structure |
|