| Reaction Details |
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 | Report a problem with these data |
| Target | Target of rapamycin complex 2 subunit MAPKAP1 |
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| Ligand | BDBM50535043 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1929668 (CHEMBL4432844) |
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| IC50 | 15±n/a nM |
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| Citation |  Cansfield, AD; Ladduwahetty, T; Sunose, M; Ellard, K; Lynch, R; Newton, AL; Lewis, A; Bennett, G; Zinn, N; Thomson, DW; Rüger, AJ; Feutrill, JT; Rausch, O; Watt, AP; Bergamini, G CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model. ACS Med Chem Lett7:768-73 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Target of rapamycin complex 2 subunit MAPKAP1 |
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| Name: | Target of rapamycin complex 2 subunit MAPKAP1 |
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| Synonyms: | MAPKAP1 | MIP1 | Mitogen-activated protein kinase 2-associated protein 1 | SAPK-interacting protein 1 | SIN1 | SIN1_HUMAN | Stress-activated map kinase-interacting protein 1 | TORC2 subunit MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 | mSIN1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59129.70 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119716 |
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| Residue: | 522 |
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| Sequence: | MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGE
TQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQEL
KSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVY
LPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGE
VDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVT
MKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRAD
GVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKAS
TKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVL
KVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
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| BDBM50535043 |
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| n/a |
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| Name | BDBM50535043 |
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| Synonyms: | CHEMBL4577549 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H29N5O4S |
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| Mol. Mass. | 459.562 |
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| SMILES | CCNC(=O)Nc1ccc(cc1)-c1nc2c(CS(=O)(=O)C2(C)C)c(n1)N1CCOC[C@@H]1C |r| |
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| Structure | 
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