| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Heme oxygenase 2 |
|---|
| Ligand | BDBM50526845 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1930142 (CHEMBL4433393) |
|---|
| IC50 | 4300±n/a nM |
|---|
| Citation |  Salerno, L; Floresta, G; Ciaffaglione, V; Gentile, D; Margani, F; Turnaturi, R; Rescifina, A; Pittalą, V Progress in the development of selective heme oxygenase-1 inhibitors and their potential therapeutic application. Eur J Med Chem167:439-453 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Heme oxygenase 2 |
|---|
| Name: | Heme oxygenase 2 |
|---|
| Synonyms: | HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 35754.99 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | HO-2 obtained from rat brain was used in enzyme assays. |
|---|
| Residue: | 315 |
|---|
| Sequence: | MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGN
IKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENW
EEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTG
EGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAG
SMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILA
ASVALVAGLLAWYYM
|
|
|
|---|
| BDBM50526845 |
|---|
| n/a |
|---|
| Name | BDBM50526845 |
|---|
| Synonyms: | CHEMBL4454118 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23ClN2 |
|---|
| Mol. Mass. | 350.884 |
|---|
| SMILES | Clc1ccc(Cn2c(CC3CC4CCC3C4)nc3ccccc23)cc1 |TLB:8:9:15:12.13| |
|---|
| Structure | 
|
|---|
Search and Browse
