| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 2 |
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| Ligand | BDBM50531540 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1930250 (CHEMBL4433501) |
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| IC50 | 15±n/a nM |
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| Citation |  Zeidan, MA; Mostafa, AS; Gomaa, RM; Abou-Zeid, LA; El-Mesery, M; El-Sayed, MA; Selim, KB Design, synthesis and docking study of novel picolinamide derivatives as anticancer agents and VEGFR-2 inhibitors. Eur J Med Chem168:315-329 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 2 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 2 |
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| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 2 (MEK2) | Dual specificity mitogen-activated protein kinase kinase; MEK1/2 | ERK activator kinase 2 | MAP kinase kinase 2 | MAP2K2 | MAPK/ERK kinase 2 | MAPKK 2 | MEK2 | MKK2 | MP2K2_HUMAN | PRKMK2 | VHL-MAP2K1/MAP2K2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44423.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_13489054 |
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| Residue: | 400 |
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| Sequence: | MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ
GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP
PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL
KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
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| BDBM50531540 |
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| n/a |
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| Name | BDBM50531540 |
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| Synonyms: | CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057 | JTP-74057 | Mekinist | TMT-212 | Tmt212 | Trametinib | US11147816, Trametinib | US11701360, Trametinib |
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| Type | Small organic molecule |
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| Emp. Form. | C26H23FIN5O4 |
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| Mol. Mass. | 615.3948 |
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| SMILES | CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O |
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| Structure | 
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