| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-1 |
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| Ligand | BDBM50535358 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1930270 (CHEMBL4433521) |
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| IC50 | >100000±n/a nM |
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| Citation |  Farooqi, AS; Hong, JY; Cao, J; Lu, X; Price, IR; Zhao, Q; Kosciuk, T; Yang, M; Bai, JJ; Lin, H Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model. J Med Chem62:4131-4141 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-1 |
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| Name: | NAD-dependent protein deacetylase sirtuin-1 |
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| Synonyms: | NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2 |
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| Type: | Developmental protein; hydrolase |
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| Mol. Mass.: | 81626.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 747 |
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| Sequence: | MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
GDDQEAINEAISVKQEVTDMNYPSNKS
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| BDBM50535358 |
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| n/a |
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| Name | BDBM50535358 |
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| Synonyms: | CHEMBL4569471 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H28N4O4S |
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| Mol. Mass. | 444.547 |
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| SMILES | CNC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc(O)c1 |r| |
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| Structure | 
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