| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase TAO2 |
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| Ligand | BDBM50536333 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1933645 (CHEMBL4479297) |
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| IC50 | 600±n/a nM |
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| Citation |  Piala, AT; Akella, R; Potts, MB; Dudics-Giagnocavo, SA; He, H; Wei, S; White, MA; Posner, BA; Goldsmith, EJ Discovery of novel TAOK2 inhibitor scaffolds from high-throughput screening. Bioorg Med Chem Lett26:3923-7 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase TAO2 |
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| Name: | Serine/threonine-protein kinase TAO2 |
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| Synonyms: | 2.7.11.1 | Serine/threonine-protein kinase TAO2 | TAOK2_RAT | Tao2 | Taok2 | Thousand and one amino acid protein 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 138761.39 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_119215 |
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| Residue: | 1235 |
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| Sequence: | MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS
YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK
KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
ESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA
VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS
ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEEEGPESREMAMMQEGEHTVTSHSSIIHR
LPGSDNLYDDPYQPEMTPGPLQPPAAPPTSTSSSSARRRAYCRNRDHFATIRTASLVSRQ
IQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSGRLQRELEAQRAGFGTE
AEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEEL
QENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLD
QDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQL
EYNKRREQELRQKHAAQVRQQPKSLKVRAGQLPMGLPATGALGPLSTGTLSEEQPCSSGQ
EAILGQRMLGEEEEAVPERMILGKEGTTLEPEEQRILGEEMGTFSSSPQKHRSLVNEEDW
DISKEMKESRVPSLASQERNIIGQEEAGAWNLWEKEHGNLVDMEFKLGWVQGPVLTPVPE
EEEEEEEEGGAPIGTPRDPGDGCPSPDIPPEPPPSHLRQYPASQLPGFLSHGLLTGLSFA
VGSSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLFLCTALHLPPSLFL
LLAQGTALGAVLSLSWRRGLMGVPLGLGAAWLLAWPSLALPLAAMAAGGKWVRQQGPQMR
RGISRLWLRVLLRLSPMVFRALQGCAAVGDRGLFALYPKTNKNGFRSRLPVPWPRQGNPR
TTQHPLALLARVWALCKGWNWRLARASHRLASCLPPWAVHILASWGLLKGERPSRIPRLL
PRSQRRLGLSASRQLPPGTVAGRRSQTRRALPPWR
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| BDBM50536333 |
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| n/a |
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| Name | BDBM50536333 |
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| Synonyms: | CHEMBL4550547 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N2O4S |
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| Mol. Mass. | 446.518 |
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| SMILES | O=C(NCC1COc2ccccc2O1)c1ccc2CC(=S)N(CC3=CC=CC3)C(=O)c2c1 |c:27,t:25| |
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| Structure | 
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