| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50093089 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_205877 |
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| Ki | 33±n/a nM |
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| Citation |  Reichard, GA; Ball, ZT; Aslanian, R; Anthes, JC; Shih, NY; Piwinski, JJ The design and synthesis of novel NK1/NK2 dual antagonists. Bioorg Med Chem Lett10:2329-32 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50093089 |
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| n/a |
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| Name | BDBM50093089 |
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| Synonyms: | (S)-1-(3,5-Bis-trifluoromethyl-benzyloxy)-3-(3,4-dichloro-phenyl)-5-(4-hydroxy-4-phenyl-piperidin-1-yl)-pentan-2-one O-methyl-oxime | CHEMBL311387 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H32Cl2F6N2O3 |
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| Mol. Mass. | 677.504 |
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| SMILES | CO\N=C(/COCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)[C@@H](CCN1CCC(O)(CC1)c1ccccc1)c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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