| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Toll-like receptor 7 |
|---|
| Ligand | BDBM50240849 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1970870 (CHEMBL4603688) |
|---|
| EC50 | 6800±n/a nM |
|---|
| Citation |  Hunt, JR; Kleindl, PA; Moulder, KR; Prisinzano, TE; Forrest, ML Further exploration of the structure-activity relationship of imidazoquinolines; identification of potent C7-substituted imidazoquinolines. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Toll-like receptor 7 |
|---|
| Name: | Toll-like receptor 7 |
|---|
| Synonyms: | ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 120945.35 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NYK1 |
|---|
| Residue: | 1049 |
|---|
| Sequence: | MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV
|
|
|
|---|
| BDBM50240849 |
|---|
| n/a |
|---|
| Name | BDBM50240849 |
|---|
| Synonyms: | 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine | 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine | 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline | CHEMBL1282 | IMIQUIMOD | R 837 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H16N4 |
|---|
| Mol. Mass. | 240.3036 |
|---|
| SMILES | CC(C)Cn1cnc2c(N)nc3ccccc3c12 |
|---|
| Structure | 
|
|---|
Search and Browse
