| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 8 |
|---|
| Ligand | BDBM50538735 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1976995 (CHEMBL4610130) |
|---|
| IC50 | 780±n/a nM |
|---|
| Citation |  Banerjee, S; Adhikari, N; Amin, SA; Jha, T Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview. Eur J Med Chem164:214-240 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 8 |
|---|
| Name: | Histone deacetylase 8 |
|---|
| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41749.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9BY41 |
|---|
| Residue: | 377 |
|---|
| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
|
|
|
|---|
| BDBM50538735 |
|---|
| n/a |
|---|
| Name | BDBM50538735 |
|---|
| Synonyms: | CHEMBL2371802 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H41F5N4O6 |
|---|
| Mol. Mass. | 660.6725 |
|---|
| SMILES | [H][C@]12CCCN1C(=O)[C@@]([H])(NC(=O)[C@@H](Cc1ccc(OC)cc1)NC(=O)[C@H](CCCCCC(=O)C(F)(F)C(F)(F)F)NC2=O)[C@@H](C)CC |
|---|
| Structure | 
|
|---|
Search and Browse
