Reaction Details |
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Target | Palmitoleoyl-protein carboxylesterase NOTUM |
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Ligand | BDBM50539206 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1977817 (CHEMBL4610952) |
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IC50 | 220±n/a nM |
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Citation | Atkinson, BN; Steadman, D; Mahy, W; Zhao, Y; Sipthorp, J; Bayle, ED; Svensson, F; Papageorgiou, G; Jeganathan, F; Frew, S; Monaghan, A; Bictash, M; Jones, EY; Fish, PV Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Palmitoleoyl-protein carboxylesterase NOTUM |
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Name: | Palmitoleoyl-protein carboxylesterase NOTUM |
Synonyms: | NOTUM | NOTUM_HUMAN | Palmitoleoyl-protein carboxylesterase NOTUM | hNOTUM |
Type: | PROTEIN |
Mol. Mass.: | 55706.36 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_116492 |
Residue: | 496 |
Sequence: | MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVE
GNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRW
LLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFI
PYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLL
NVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNG
VVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGL
RLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHD
SHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQP
QGLEPSELLGMLSNGS
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BDBM50539206 |
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n/a |
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Name | BDBM50539206 |
Synonyms: | CHEMBL4638233 |
Type | Small organic molecule |
Emp. Form. | C14H16ClN3OS2 |
Mol. Mass. | 341.879 |
SMILES | Cc1sc2ncnc(SCC(=O)N3CCCCC3)c2c1Cl |
Structure |
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