| Reaction Details |
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 | Report a problem with these data |
| Target | Ataxin-2 |
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| Ligand | BDBM50539260 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1977878 (CHEMBL4611013) |
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| IC50 | 50±n/a nM |
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| Citation |  Gerokonstantis, DT; Nikolaou, A; Magkrioti, C; Afantitis, A; Aidinis, V; Kokotos, G; Moutevelis-Minakakis, P Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme. Bioorg Med Chem28:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ataxin-2 |
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| Name: | Ataxin-2 |
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| Synonyms: | ATX2_MOUSE | Ataxin-2 | Atx2 | Atxn2 | Sca2 | Spinocerebellar ataxia type 2 protein homolog |
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| Type: | PROTEIN |
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| Mol. Mass.: | 136544.55 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_119897 |
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| Residue: | 1285 |
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| Sequence: | MRSSTAAVQRPAAGDPEPRRPAGWAARRSLPRTARRGGRGGAVAYPSAGPPPRGPGAPPR
GPRSPPCASDCFGSNGHGASRPGSRRLLGVCGPPRPFVVVLLALAPAATPARACPPGVRA
SPPRSGVSSSARPAPGCPRPACEPVYGPLTMSLKPQPQPPAPATGRKPGGGLLSSPGAAP
ASAAVTSASVVPAPAAPVASSSAAAGGGRPGLGRGRNSSKGLPQPTISFDGIYANVRMVH
ILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESVLF
KCSDFVVVQFKDTDSSYARRDAFTDSALSAKVNGEHKEKDLEPWDAGELTASEELELEND
VSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESS
AQYKARVALENDDRSEEEKYTAVQRNCSDREGHGPNTRDNKYIPPGQRNREVLSWGSGRQ
SSPRMGQPGPGSMPSRAASHTSDFNPNAGSDQRVVNGGVPWPSPCPSHSSRPPSRYQSGP
NSLPPRAATHTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHP
RNHRVSAGRGSMSSGLEFVSHNPPSEAAAPPVARTSPAGGTWSSVVSGVPRLSPKTHRPR
SPRQSSIGNSPSGPVLASPQAGIIPAEAVSMPVPAASPTPASPASNRALTPSIEAKDSRL
QDQRQNSPAGSKENVKASETSPSFSKADNKGMSPVVSEHRKQIDDLKKFKNDFRLQPSST
SESMDQLLSKNREGEKSRDLIKDKTEASAKDSFIDSSSSSSNCTSGSSKTNSPSISPSML
SNAEHKRGPEVTSQGVQTSSPACKQEKDDREEKKDTTEQVRKSTLNPNAKEFNPRSFSQP
KPSTTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPM
PVNQAKTYRAGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSPQQFP
NQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAHAQPGLVSSSAAQFGAHEQTHAMYAC
PKLPYNKETSPSFYFAISTGSLAQQYAHPNAALHPHTPHPQPSATPTGQQQSQHGGSHPA
PSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQSSFPAAQQTVFT
IHPSHVQPAYTTPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGPKAALAQSALQP
IPVSTTAHFPYMTHPSVQAHHQQQL
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| BDBM50539260 |
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| n/a |
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| Name | BDBM50539260 |
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| Synonyms: | CHEMBL4640637 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H37BN2O5 |
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| Mol. Mass. | 540.458 |
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| SMILES | CC1(C)OB(OC1(C)C)c1ccc(COc2ccc(CNC(=O)[C@@H]3CCC(=O)N3Cc3ccccc3)cc2)cc1 |r| |
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| Structure | 
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