| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear factor erythroid 2-related factor 2 |
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| Ligand | BDBM50539554 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1978289 (CHEMBL4611424) |
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| EC50 | 2820±n/a nM |
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| Citation |  Ma, B; Lucas, B; Capacci, A; Lin, EY; Jones, JH; Dechantsreiter, M; Enyedy, I; Marcotte, D; Xiao, G; Li, B; Richter, K Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear factor erythroid 2-related factor 2 |
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| Name: | Nuclear factor erythroid 2-related factor 2 |
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| Synonyms: | HEBP1 | Kelch-like ECH-associated protein 1 | NF-E2-related factor 2 | NF2L2_HUMAN | NFE2-related factor 2 | NFE2L2 | NRF2 | Nuclear factor erythroid 2-related factor 2 | Nuclear factor, erythroid derived 2, like 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67786.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107924 |
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| Residue: | 605 |
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| Sequence: | MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQE
QLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCM
QLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGM
QQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVG
NCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMP
SPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHS
VESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDA
QCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVD
FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLL
KEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKP
DVKKN
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| BDBM50539554 |
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| n/a |
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| Name | BDBM50539554 |
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| Synonyms: | CHEMBL4638963 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H40N4O3 |
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| Mol. Mass. | 552.7064 |
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| SMILES | CC[C@H]([C@@H](c1ccc2CCN(Cc2c1)C(=O)c1c(C)c(C)cc(C)c1C)c1ccc2n(CC)nnc2c1C)C(O)=O |r| |
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| Structure | 
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