| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E synthase |
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| Ligand | BDBM50539780 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1979320 (CHEMBL4612455) |
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| IC50 | 2600±n/a nM |
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| Citation |  Chini, MG; Giordano, A; Potenza, M; Terracciano, S; Fischer, K; Vaccaro, MC; Colarusso, E; Bruno, I; Riccio, R; Koeberle, A; Werz, O; Bifulco, G Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE ACS Med Chem Lett11:783-789 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E synthase |
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| Name: | Prostaglandin E synthase |
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| Synonyms: | MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1) |
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| Type: | Protein |
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| Mol. Mass.: | 17112.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 152 |
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| Sequence: | MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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| BDBM50539780 |
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| n/a |
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| Name | BDBM50539780 |
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| Synonyms: | CHEMBL4643829 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18N2O3S |
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| Mol. Mass. | 378.444 |
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| SMILES | Cc1cc(C)c(o1)C(=O)Nc1nc2ccc(cc2s1)-c1cccc(CO)c1 |
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| Structure | 
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