| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Trypanothione reductase |
|---|
| Ligand | BDBM50096074 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_210045 (CHEMBL812446) |
|---|
| IC50 | 39000±n/a nM |
|---|
| Citation |  Salmon-Chemin, L; Buisine, E; Yardley, V; Kohler, S; Debreu, MA; Landry, V; Sergheraert, C; Croft, SL; Krauth-Siegel, RL; Davioud-Charvet, E 2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity. J Med Chem44:548-65 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Trypanothione reductase |
|---|
| Name: | Trypanothione reductase |
|---|
| Synonyms: | N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | TR | TYTR_TRYCR |
|---|
| Type: | Homodimer; oxidoreductase |
|---|
| Mol. Mass.: | 53868.26 |
|---|
| Organism: | Trypanosoma cruzi |
|---|
| Description: | n/a |
|---|
| Residue: | 492 |
|---|
| Sequence: | MMSKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVP
KKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKKLIAVKDEAVLNINKSYEEMFRDTEG
LEFFLGWGSLESKNVVNVRESADPASAVKERLETENILLASGSWPHMPNIPGIEHCISSN
EAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELT
KQLTANGIQILTKENPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNA
GVMIKNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTNPRKTDHT
RVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHNISGSKYKTFVAKIITNHS
DGTVLGVHLLGDNAPEIIQGVGICLKLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVK
GEKMEKPSEASL
|
|
|
|---|
| BDBM50096074 |
|---|
| n/a |
|---|
| Name | BDBM50096074 |
|---|
| Synonyms: | 3-{3-[4-(3-Amino-propyl)-piperazin-1-yl]-propylamino}-5-hydroxy-2-methyl-[1,4]naphthoquinone | CHEMBL348714 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H30N4O3 |
|---|
| Mol. Mass. | 386.4879 |
|---|
| SMILES | Cc1c(O)c2cccc(O)c2c(O)c1N=CCCN1CCN(CCCN)CC1 |w:15.17| |
|---|
| Structure | 
|
|---|
Search and Browse
