Reaction Details |
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Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Ligand | BDBM477620 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1981751 (CHEMBL4615013) |
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IC50 | 40±n/a nM |
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Citation | Popova, G; Ladds, MJGW; Johansson, L; Saleh, A; Larsson, J; Sandberg, L; Sahlberg, SH; Qian, W; Gullberg, H; Garg, N; Gustavsson, AL; Haraldsson, M; Lane, D; Yngve, U; Lain, S Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability. J Med Chem63:3915-3934 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 42881.33 |
Organism: | Homo sapiens (Human) |
Description: | Q02127 |
Residue: | 395 |
Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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BDBM477620 |
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n/a |
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Name | BDBM477620 |
Synonyms: | N-[(4R)-1-(2-fluoro-5-methylphenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl]-4-(trifluoromethyl)pyridine-2-carboxamide | US10889564, Example 50 |
Type | Small organic molecule |
Emp. Form. | C21H18F4N4O |
Mol. Mass. | 418.3874 |
SMILES | Cc1ccc(F)c(c1)-n1ncc2[C@@H](CCCc12)NC(=O)c1cc(ccn1)C(F)(F)F |r| |
Structure |
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