| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM477602 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1981751 (CHEMBL4615013) |
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| IC50 | 30±n/a nM |
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| Citation |  Popova, G; Ladds, MJGW; Johansson, L; Saleh, A; Larsson, J; Sandberg, L; Sahlberg, SH; Qian, W; Gullberg, H; Garg, N; Gustavsson, AL; Haraldsson, M; Lane, D; Yngve, U; Lain, S Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability. J Med Chem63:3915-3934 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 42881.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02127 |
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| Residue: | 395 |
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| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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| BDBM477602 |
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| n/a |
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| Name | BDBM477602 |
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| Synonyms: | Ethyl 3-[4-(4,5,6,7-tetrahydro-1,2-benzoxazole-3-amido)-4,5,6,7-tetrahydro-1H-indazol-1-yl]benzoate | US10889564, Example 32 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N4O4 |
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| Mol. Mass. | 434.4876 |
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| SMILES | CCOC(=O)c1cccc(c1)-n1ncc2C(CCCc12)NC(=O)c1noc2CCCCc12 |
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| Structure | 
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