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TargetDihydroorotate dehydrogenase (quinone), mitochondrial
LigandBDBM477599
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1981812 (CHEMBL4615074)
IC50 3.5±n/a nM
Citation Popova, G; Ladds, MJGW; Johansson, L; Saleh, A; Larsson, J; Sandberg, L; Sahlberg, SH; Qian, W; Gullberg, H; Garg, N; Gustavsson, AL; Haraldsson, M; Lane, D; Yngve, U; Lain, S Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability. J Med Chem63:3915-3934 (2020) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydroorotate dehydrogenase (quinone), mitochondrial
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:Enzyme
Mol. Mass.:42881.33
Organism:Homo sapiens (Human)
Description:Q02127
Residue:395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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  Blast E-value cutoff:
BDBM477599
n/a
NameBDBM477599
Synonyms:N-[1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl]-4,5,6,7-tetrahydro-1,2-benzoxazole-3-carboxamide | US10889564, Example 29
TypeSmall organic molecule
Emp. Form.C22H24N4O2
Mol. Mass.376.4516
SMILESCc1ccccc1-n1ncc2C(CCCc12)NC(=O)c1noc2CCCCc12
Structure
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