Reaction Details |
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Target | Muscarinic acetylcholine receptor M1 |
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Ligand | BDBM50540458 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1981908 (CHEMBL4615170) |
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Ki | 0.524807±n/a nM |
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Citation | Del Bello, F; Bonifazi, A; Giorgioni, G; Piergentili, A; Sabbieti, MG; Agas, D; Dell'Aera, M; Matucci, R; Górecki, M; Pescitelli, G; Vistoli, G; Quaglia, W Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus. J Med Chem63:5763-5782 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M1 |
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Name: | Muscarinic acetylcholine receptor M1 |
Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 |
Type: | Protein |
Mol. Mass.: | 51442.54 |
Organism: | Homo sapiens (Human) |
Description: | P11229 |
Residue: | 460 |
Sequence: | MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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BDBM50540458 |
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n/a |
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Name | BDBM50540458 |
Synonyms: | CHEMBL4634230 |
Type | Small organic molecule |
Emp. Form. | C20H32INO2 |
Mol. Mass. | 445.3781 |
SMILES | [I-].C[N+](C)(C)CC1COCC(O1)(C1CCCCC1)c1ccccc1 |
Structure |
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