| Reaction Details |
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 | Report a problem with these data |
| Target | Exportin-1 |
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| Ligand | BDBM50317384 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1983302 (CHEMBL4616564) |
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| IC50 | 63000±n/a nM |
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| Citation |  Shaikhqasem, A; Dickmanns, A; Neumann, P; Ficner, R Characterization of Inhibition Reveals Distinctive Properties for Human and J Med Chem63:7545-7558 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Exportin-1 |
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| Name: | Exportin-1 |
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| Synonyms: | CRM1 | XPO1 | XPO1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 123374.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_635789 |
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| Residue: | 1071 |
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| Sequence: | MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAW
TRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCV
EKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFD
FSSGQITQVKSKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGY
IFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFVTLFTLTMMQLKQMLPL
NTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHDQLIEKRLNLRETLMEALHYMLLVSEV
EETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDVPPRRQLYLPMLFKVRLLM
VSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTERIMTEKL
HNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAII
ASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFV
QVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLL
PNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNV
YKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPL
LDAVLIDYQRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEE
YPEHRTNFFLLLQAVNSHCFPAFLAIPPTQFKLVLDSIIWAFKHTMRNVADTGLQILFTL
LQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKIST
SLNPGNPVNNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLV
QIKEFAGEDTSDLFLEEREIALRQADEEKHKRQMSVPGIFNPHEIPEEMCD
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| BDBM50317384 |
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| n/a |
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| Name | BDBM50317384 |
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| Synonyms: | CHEMBL1096042 | ethyl 5-(4-nitrophenyl)-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10N4O6 |
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| Mol. Mass. | 330.2524 |
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| SMILES | CCOC(=O)c1n[nH]c2C(=O)N(C(=O)c12)c1ccc(cc1)[N+]([O-])=O |
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| Structure | 
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