| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-glucuronidase |
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| Ligand | BDBM227609 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1983575 (CHEMBL4616981) |
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| IC50 | 500±n/a nM |
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| Citation |  Awolade, P; Cele, N; Kerru, N; Gummidi, L; Oluwakemi, E; Singh, P Therapeutic significance of ?-glucuronidase activity and its inhibitors: A review. Eur J Med Chem187:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-glucuronidase |
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| Name: | Beta-glucuronidase |
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| Synonyms: | β-Glucuronidase | BGLR_HUMAN | Beta-G1 | Beta-glucuronidase | GUSB | beta-Glucuronidase (β-glucuronidase) |
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| Type: | Protein |
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| Mol. Mass.: | 74736.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 651 |
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| Sequence: | MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFE
EQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVV
LRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTT
LPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQD
SGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYL
YSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKG
FDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNN
VSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVT
FVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSE
YGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTR
VLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT
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| BDBM227609 |
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| n/a |
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| Name | BDBM227609 |
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| Synonyms: | (E)-5-chloro-N'-(2,4,5-trihydroxybenzylidene)-1H-indole-2-carbohydrazide (10) |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12ClN3O4 |
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| Mol. Mass. | 345.737 |
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| SMILES | Oc1cc(O)c(\C=N\NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1O |
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| Structure | 
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