| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fusion glycoprotein F0 |
|---|
| Ligand | BDBM50541842 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1985451 (CHEMBL4618857) |
|---|
| EC50 | 440±n/a nM |
|---|
| Citation |  Yamaguchi-Sasaki, T; Tokura, S; Ogata, Y; Kawaguchi, T; Sugaya, Y; Takahashi, R; Iwakiri, K; Abe-Kumasaka, T; Yoshida, I; Arikawa, K; Sugiyama, H; Kanuma, K Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins. ACS Med Chem Lett11:1145-1151 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fusion glycoprotein F0 |
|---|
| Name: | Fusion glycoprotein F0 |
|---|
| Synonyms: | F | FUS_HRSVA | Fusion glycoprotein F0 | Fusion glycoprotein F1 | Fusion glycoprotein F2 | Intervening segment | Pep27 | Peptide 27 | p27 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 63471.29 |
|---|
| Organism: | Human respiratory syncytial virus A (strain A2) |
|---|
| Description: | ChEMBL_116942 |
|---|
| Residue: | 574 |
|---|
| Sequence: | MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIE
LSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPPTNNRARRELPRFMNYTLN
NAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVS
LSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVN
AGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYV
VQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKV
QSNRVFCDTMNSLTLPSEINLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKT
KCTASNKNRGIIKTFSNGCDYVSNKGMDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDP
LVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLS
LIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN
|
|
|
|---|
| BDBM50541842 |
|---|
| n/a |
|---|
| Name | BDBM50541842 |
|---|
| Synonyms: | CHEMBL4647328 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H37N7O2 |
|---|
| Mol. Mass. | 491.6284 |
|---|
| SMILES | CC[C@@H]1N(C)C(=O)c2cc(C)ccc2OCCCCN(C)c2cc(nc3cc1nn23)N1CC[C@H](N)C1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
