| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate carboxypeptidase 2 |
|---|
| Ligand | BDBM50099221 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_158618 (CHEMBL765764) |
|---|
| IC50 | 3500±n/a nM |
|---|
| Citation |  Adlington, RM; Baldwin, JE; Becker, GW; Chen, B; Cheng, L; Cooper, SL; Hermann, RB; Howe, TJ; McCoull, W; McNulty, AM; Neubauer, BL; Pritchard, GJ Design, synthesis, and proposed active site binding analysis of monocyclic 2-azetidinone inhibitors of prostate specific antigen. J Med Chem44:1491-508 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutamate carboxypeptidase 2 |
|---|
| Name: | Glutamate carboxypeptidase 2 |
|---|
| Synonyms: | FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 84333.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1497035 |
|---|
| Residue: | 750 |
|---|
| Sequence: | MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA
|
|
|
|---|
| BDBM50099221 |
|---|
| n/a |
|---|
| Name | BDBM50099221 |
|---|
| Synonyms: | (2S,3S)-1-[2-(3-Benzyloxycarbonyl-phenyl)-acetyl]-3-(4-hydroxy-benzyl)-4-oxo-azetidine-2-carboxylic acid 4-carboxy-benzyl ester | 1-[2-(3-Benzyloxycarbonyl-phenyl)-acetyl]-3-(4-hydroxy-benzyl)-4-oxo-azetidine-2-carboxylic acid 4-carboxy-benzyl ester | CHEMBL284762 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H29NO9 |
|---|
| Mol. Mass. | 607.6061 |
|---|
| SMILES | OC(=O)c1ccc(COC(=O)[C@@H]2[C@H](Cc3ccc(O)cc3)C(=O)N2C(=O)Cc2cccc(c2)C(=O)OCc2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
