| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM21974 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1988113 (CHEMBL4621660) |
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| IC50 | 6500000±n/a nM |
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| Citation |  Duff, MR; Gabel, SA; Pedersen, LC; DeRose, EF; Krahn, JM; Howell, EE; London, RE The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase. J Med Chem63:8314-8324 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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|
|
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| BDBM21974 |
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| n/a |
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| Name | BDBM21974 |
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| Synonyms: | (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid | CHEMBL54976 | L-tryptophan | US11021454, Compound L-trp | US9138393, L-Tryptophan | US9144538, L-Tryptophan |
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| Type | Amino Acid |
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| Emp. Form. | C11H12N2O2 |
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| Mol. Mass. | 204.2252 |
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| SMILES | N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O |
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| Structure | 
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