| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50016799 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1988113 (CHEMBL4621660) |
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| Ki | 1800000±n/a nM |
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| Citation |  Duff, MR; Gabel, SA; Pedersen, LC; DeRose, EF; Krahn, JM; Howell, EE; London, RE The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase. J Med Chem63:8314-8324 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50016799 |
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| n/a |
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| Name | BDBM50016799 |
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| Synonyms: | (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid | 2-(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid | AY-24236 | CHEMBL622 | ETODOLAC | Etodolic Acid | Lodine | Lodine xl |
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| Type | Small organic molecule |
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| Emp. Form. | C17H21NO3 |
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| Mol. Mass. | 287.3535 |
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| SMILES | CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12 |
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| Structure | 
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