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TargetDihydrofolate reductase
LigandBDBM50542901
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1988113 (CHEMBL4621660)
Ki 180000±n/a nM
Citation Duff, MRGabel, SAPedersen, LCDeRose, EFKrahn, JMHowell, EELondon, RE The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase. J Med Chem63:8314-8324 (2020) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50542901
n/a
NameBDBM50542901
Synonyms:Diaminopyrimidine
TypeSmall organic molecule
Emp. Form.C4H6N4
Mol. Mass.110.1172
SMILESNc1ccnc(N)n1
Structure
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