Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50542901 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1988113 (CHEMBL4621660) |
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Ki | 180000±n/a nM |
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Citation | Duff, MR; Gabel, SA; Pedersen, LC; DeRose, EF; Krahn, JM; Howell, EE; London, RE The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase. J Med Chem63:8314-8324 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50542901 |
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n/a |
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Name | BDBM50542901 |
Synonyms: | Diaminopyrimidine |
Type | Small organic molecule |
Emp. Form. | C4H6N4 |
Mol. Mass. | 110.1172 |
SMILES | Nc1ccnc(N)n1 |
Structure |
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