Ki Summary

Reaction Details

Report a problem with these data

Target

Vitamin D3 receptor

Ligand

BDBM50544012

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1991216 (CHEMBL4624951)

IC50

3552±n/a nM

Citation

Masuda, A; Gohda, K; Iguchi, Y; Fujimori, K; Yamashita, Y; Oda, K; Une, M; Teno, N N Bioorg Med Chem28:0 (2020) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Vitamin D3 receptor

Name:

Vitamin D3 receptor

Synonyms:

Type:

Protein

Mol. Mass.:

48288.72

Organism:

Homo sapiens (Human)

Description:

P11473

Residue:

427

Sequence:

MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFGNEIS

BDBM50544012

n/a

Name

BDBM50544012

Synonyms:

CHEMBL4632880

Type

Small organic molecule

Emp. Form.

C30H27Cl2N3O4

Mol. Mass.

564.459

SMILES

CC(C)c1onc(c1COc1ccc(cc1)-c1nc2ccc(cc2n1C(C)C)C(O)=O)-c1c(Cl)cccc1Cl |(35.36,-53.52,;35.99,-52.11,;37.52,-51.95,;35.08,-50.87,;33.54,-50.87,;33.07,-49.4,;34.31,-48.49,;35.56,-49.4,;37.02,-48.92,;38.17,-49.95,;39.64,-49.48,;40.78,-50.51,;42.24,-50.04,;42.57,-48.53,;41.41,-47.49,;39.95,-47.98,;44.03,-48.05,;45.27,-48.95,;46.52,-48.04,;48.02,-48.36,;49.05,-47.21,;48.57,-45.75,;47.07,-45.44,;46.05,-46.58,;44.5,-46.58,;43.59,-45.34,;44.21,-43.93,;42.07,-45.5,;49.58,-44.59,;51.1,-44.91,;49.1,-43.13,;34.3,-46.95,;35.64,-46.17,;36.98,-46.95,;35.63,-44.62,;34.3,-43.86,;32.97,-44.63,;32.96,-46.18,;31.63,-46.95,)|

Structure