| Reaction Details |
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 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
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| Ligand | BDBM50371060 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1992783 (CHEMBL4626518) |
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| IC50 | <10.0±n/a nM |
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| Citation |  Williams, NS; Gonzales, S; Naidoo, J; Rivera-Cancel, G; Voruganti, S; Mallipeddi, P; Theodoropoulos, PC; Geboers, S; Chen, H; Ortiz, F; Posner, B; Nijhawan, D; Ready, JM Tumor-Activated Benzothiazole Inhibitors of Stearoyl-CoA Desaturase. J Med Chem63:9773-9786 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stearoyl-CoA desaturase |
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| Name: | Stearoyl-CoA desaturase |
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| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41537.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00767 |
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| Residue: | 359 |
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| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
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| BDBM50371060 |
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| n/a |
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| Name | BDBM50371060 |
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| Synonyms: | CHEMBL226646 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17ClFN5O2 |
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| Mol. Mass. | 389.811 |
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| SMILES | Cc1nnc(o1)-c1ccc(nn1)N1CCC(CC1)Oc1cc(F)ccc1Cl |
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| Structure | 
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