Ki Summary

Reaction Details

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Target

Prostaglandin E2 receptor EP4 subtype

Ligand

BDBM50101843

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_158450 (CHEMBL763254)

7±n/a nM

Citation

Maruyama, T; Asada, M; Shiraishi, T; Ishida, A; Egashira, H; Yoshida, H; Maruyama, T; Ohuchida, S; Nakai, H; Kondo, K; Toda, M Design and synthesis of a highly selective EP4-receptor agonist. Part 1: 3,7-dithiaPG derivatives with high selectivity. Bioorg Med Chem Lett11:2029-31 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Prostaglandin E2 receptor EP4 subtype

Name:

Prostaglandin E2 receptor EP4 subtype

Synonyms:

PE2R4_MOUSE | PGE receptor, EP4 subtype | Prostanoid EP4 receptor | Ptger4 | Ptgerep4

Type:

G-protein coupled receptor

Mol. Mass.:

56175.66

Organism:

Mus musculus (Mouse)

Description:

n/a

Residue:

513

Sequence:

MAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGN
LVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYS
TFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPN
MGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHR
QFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVI
LLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILL
RKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTS
QTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVD
EVSGSHREEPASKGNSLQVTFPSETLKLSEKCI

BDBM50101843

n/a

Name

BDBM50101843

Synonyms:

CHEMBL64542 | {3-[(1R,2S,3R)-3-Hydroxy-2-((E)-(S)-3-hydroxy-4-phenyl-but-1-enyl)-5-oxo-cyclopentylsulfanyl]-propylsulfanyl}-acetic acid

Type

Small organic molecule

Emp. Form.

C20H26O5S2

Mol. Mass.

410.547

SMILES

O[C@@H](Cc1ccccc1)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(O)=O

Structure