| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 4 |
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| Ligand | BDBM50545037 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1994277 (CHEMBL4628172) |
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| IC50 | 51±n/a nM |
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| Citation |  Lawhorn, BG; Brnardic, EJ; Behm, DJ Recent advances in TRPV4 agonists and antagonists. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential cation channel subfamily V member 4 |
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| Name: | Transient receptor potential cation channel subfamily V member 4 |
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| Synonyms: | TRPV4 | TRPV4_HUMAN | Transient receptor potential cation channel subfamily V member 4 (TRPV4) | VRL2 | VROAC |
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| Type: | Enzyme |
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| Mol. Mass.: | 98290.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9HBA0 |
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| Residue: | 871 |
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| Sequence: | MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGP
GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDN
KRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRL
TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT
ALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI
VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDS
NLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYD
LSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLC
AMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGV
NSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTG
TYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSC
RDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGE
TVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRV
DEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDE
VVVPLDSMGNPRCDGHQQGYPRKWRTDDAPL
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| BDBM50545037 |
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| n/a |
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| Name | BDBM50545037 |
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| Synonyms: | CHEMBL4633175 |
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| Type | Small organic molecule |
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| Emp. Form. | C58H62N2O10 |
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| Mol. Mass. | 947.1203 |
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| SMILES | [H][C@@]12[#8]-[#6](=O)-c3ccccc3-[#7]1-[#6@@H](\[#6]=[#6]\[#6])[C@@]([H])([#6@@H](-[#7]-c1ccccc1-[#6](-[#8])=O)-c1c3-[#8]C([#6])([#6])[#6@@H](-[#8])-[#6](=O)-c3cc(-[#6]\[#6]=[#6](\[#6])-[#6])c1\[#6]=[#6]\[#6]=[#6]\[#6])c1c(-[#6]\[#6]=[#6](\[#6])-[#6])cc3-[#6](=O)-[#6@@H](-[#8])C([#6])([#6])[#8]-c3c21 |r| |
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| Structure | 
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