| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50545172 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1994446 (CHEMBL4628341) |
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| IC50 | 7000±n/a nM |
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| Citation |  Koval, VS; Arutyunyan, AF; Salyanov, VI; Kostyukov, AA; Melkina, OE; Zavilgelsky, GB; Klimova, RR; Kushch, AA; Korolev, SP; Agapkina, YY; Gottikh, MB; Vaiman, AV; Rybalkina, EY; Susova, OY; Zhuze, AL DNA sequence-specific ligands. XVIII. Synthesis, physico-chemical properties; genetic, virological, and biochemical studies of fluorescent dimeric bisbenzimidazoles DBPA(n). Bioorg Med Chem28:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | Human immunodeficiency virus type 1 integrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32231.48 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_90865 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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| BDBM50545172 |
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| n/a |
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| Name | BDBM50545172 |
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| Synonyms: | CHEMBL4644631 |
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| Type | Small organic molecule |
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| Emp. Form. | C50H60N16O2 |
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| Mol. Mass. | 917.1174 |
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| SMILES | CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1ccc2nc(CNC(=O)CCN3CCN(CCC(=O)NCc4nc5ccc(cc5[nH]4)-c4nc5ccc(cc5[nH]4)N4CCN(C)CC4)CC3)[nH]c2c1 |
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| Structure | 
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