| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Membrane primary amine oxidase |
|---|
| Ligand | BDBM16173 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_200171 (CHEMBL810015) |
|---|
| Ki | 10000±n/a nM |
|---|
| Citation |  Conn, C; Shimmon, R; Cordaro, F; Hargraves, TL; Ibrahim, P Combinatorial synthesis of SSAO inhibitors using sonogashira coupling: SAR of aryl propargylic amines. Bioorg Med Chem Lett11:2565-8 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Membrane primary amine oxidase |
|---|
| Name: | Membrane primary amine oxidase |
|---|
| Synonyms: | AOC3_RAT | Amine oxidase, copper containing | Aoc3 | Semicarbazide-sensitive amine oxidase/ Vascular adhesion protein 1 (SSAO/VAP-1) | Vascular adhesion protein 1 (VAP-1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 84979.78 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | O08590 |
|---|
| Residue: | 763 |
|---|
| Sequence: | MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGRLSQPLHCPSVLPSVQPQTHPGQSQPF
ADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPP
VREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLTREYQDIQ
EMIFHRELPQASGLLHHCCFYKRQGHNLLKMTTAPRGLQSGDRATWFGIYYNLSGAGFYP
HPIGLELLVDHKALDPALWTIQKVFYQGRYYESLTQLEDMFEAGLVNVVLVPDNGTGGSW
SLKSSVPPGRAPPLQFHPEGPRFSVQGSQVRSSLWAFSFGLGAFSGPRIFDIRFQGERVA
YEISVQEAIALYGGNSPASMSTCYMDGSFGIGKYSTPLTRGVDCPYLATYVDWHFLLESQ
TPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVETVLVVRSVATLLNYDYVWDMVFH
SNGAIEVKFHATGYITSAFFFGAGEKFGNRVAEHTLGTVHTHNAHFKVDLDVAGLKNWAW
AEDLAFVPMNVPWQPEFQMQRLQVTRKLLETEEEAAFPLGNATPRYLYLASNHSNKWGHR
RGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIYNQNDPWTPTVDF
TDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSP
DSIYFRKDQDVTDCEVNSLACLSQTANCVPDLPAFSHGGFTYK
|
|
|
|---|
| BDBM16173 |
|---|
| n/a |
|---|
| Name | BDBM16173 |
|---|
| Synonyms: | 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinamide;hydrochloride | 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide | Amiloride | Amipramidin | CHEMBL945 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H8ClN7O |
|---|
| Mol. Mass. | 229.627 |
|---|
| SMILES | NC(=N)NC(=O)c1nc(Cl)c(N)nc1N |
|---|
| Structure | 
|
|---|
Search and Browse
