| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Target of rapamycin complex subunit LST8 |
|---|
| Ligand | BDBM50546185 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2014680 (CHEMBL4668258) |
|---|
| IC50 | 91±n/a nM |
|---|
| Citation |  Borsari, C; Rageot, D; Beaufils, F; Bohnacker, T; Keles, E; Buslov, I; Melone, A; Sele, AM; Hebeisen, P; Fabbro, D; Hillmann, P; Wymann, MP Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl-Pyrimidine Moiety. ACS Med Chem Lett10:1473-1479 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Target of rapamycin complex subunit LST8 |
|---|
| Name: | Target of rapamycin complex subunit LST8 |
|---|
| Synonyms: | G protein beta subunit-like | GBL | Gable | LST8 | LST8_HUMAN | MLST8 | Mammalian lethal with SEC13 protein 8 | Protein GbetaL | TORC subunit LST8 | Target of rapamycin complex subunit LST8 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 35871.25 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_118692 |
|---|
| Residue: | 326 |
|---|
| Sequence: | MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAA
GYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQ
CQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP
DASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA
DQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE
TGEIKREYGGHQKAVVCLAFNDSVLG
|
|
|
|---|
| BDBM50546185 |
|---|
| n/a |
|---|
| Name | BDBM50546185 |
|---|
| Synonyms: | CHEMBL4749136 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H22F2N8O2 |
|---|
| Mol. Mass. | 420.4165 |
|---|
| SMILES | [H][C@]12CC[C@]([H])(COC1)N2c1nc(nc(n1)-c1cnc(N)nc1C(F)F)N1CCOCC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
