| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50105443 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_105987 |
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| IC50 | 900000±n/a nM |
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| Citation |  Becker, DP; Barta, TE; Bedell, L; DeCrescenzo, G; Freskos, J; Getman, DP; Hockerman, SL; Li, M; Mehta, P; Mischke, B; Munie, GE; Swearingen, C; Villamil, CI alpha-Amino-beta-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1. Bioorg Med Chem Lett11:2719-22 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50105443 |
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| n/a |
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| Name | BDBM50105443 |
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| Synonyms: | CHEMBL329599 | N-[(S)-1-Hydroxycarbamoyl-2-(4-phenoxy-benzenesulfonyl)-ethyl]-isonicotinamide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19N3O6S |
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| Mol. Mass. | 441.457 |
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| SMILES | ONC(=O)[C@@H](CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)NC(=O)c1ccncc1 |
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| Structure | 
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