| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 7 |
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| Ligand | BDBM50547318 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2017490 (CHEMBL4671068) |
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| EC50 | >10000±n/a nM |
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| Citation |  Reed, CW; Kalbfleisch, JJ; Wong, MJ; Washecheck, JP; Hunter, A; Rodriguez, AL; Blobaum, AL; Conn, PJ; Niswender, CM; Lindsley, CW Discovery of VU6027459: A First-in-Class Selective and CNS Penetrant mGlu ACS Med Chem Lett11:1773-1779 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 7 |
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| Name: | Metabotropic glutamate receptor 7 |
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| Synonyms: | GRM7_RAT | Gprc1g | Grm7 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 7 (mGlu7) | Mglur7 | mGlu7 |
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| Type: | Enzyme |
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| Mol. Mass.: | 102244.48 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P35400 |
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| Residue: | 915 |
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| Sequence: | MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK
GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL
TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA
STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ
ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK
RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR
NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH
ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIF
QYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTP
CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAML
GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV
FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW
FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV
PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML
YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS
PAAKKKYVSYNNLVI
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| BDBM50547318 |
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| n/a |
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| Name | BDBM50547318 |
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| Synonyms: | CHEMBL4760187 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18FN7 |
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| Mol. Mass. | 399.4236 |
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| SMILES | Fc1ccccc1N1CCN(CC1)c1c(cnc2c(cccc12)-n1cncn1)C#N |
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| Structure | 
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