| Reaction Details |
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 | Report a problem with these data |
| Target | Transcriptional enhancer factor TEF-3 |
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| Ligand | BDBM50547137 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2017235 (CHEMBL4670813) |
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| IC50 | 8700±n/a nM |
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| Citation |  Karatas, H; Akbarzadeh, M; Adihou, H; Hahne, G; Pobbati, AV; Yihui Ng, E; Guéret, SM; Sievers, S; Pahl, A; Metz, M; Zinken, S; Dötsch, L; Nowak, C; Thavam, S; Friese, A; Kang, C; Hong, W; Waldmann, H Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain Central Pocket. J Med Chem63:11972-11989 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcriptional enhancer factor TEF-3 |
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| Name: | Transcriptional enhancer factor TEF-3 |
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| Synonyms: | RTEF1 | TCF13L1 | TEA domain family member 4 | TEAD-4 | TEAD4 | TEAD4_HUMAN | TEF3 | Transcription factor 13-like 1 | Transcription factor RTEF-1 | Transcriptional enhancer factor TEF-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48333.01 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118073 |
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| Residue: | 434 |
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| Sequence: | MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPP
CGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQ
AAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPF
SQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPD
TYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWA
DLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYR
IHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSAS
EHGAQHHIYRLVKE
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| BDBM50547137 |
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| n/a |
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| Name | BDBM50547137 |
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| Synonyms: | CHEMBL4750499 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15FN2O4 |
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| Mol. Mass. | 342.3211 |
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| SMILES | OCc1cc(=O)c(O)c(o1)C(Nc1cccc(F)c1)c1ccccn1 |
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| Structure | 
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