| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 1 |
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| Ligand | BDBM50106701 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_28947 (CHEMBL636942) |
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| IC50 | 42000±n/a nM |
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| Citation |  Giovannoni, MP; Piaz, VD; Kwon, BM; Kim, MK; Kim, YK; Toma, L; Barlocco, D; Bernini, F; Canavesi, M 5,6-Diphenylpyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors. J Med Chem44:4292-5 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 1 |
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| Name: | Sterol O-acyltransferase 1 |
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| Synonyms: | ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64165.56 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_28796 |
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| Residue: | 545 |
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| Sequence: | MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
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| BDBM50106701 |
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| n/a |
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| Name | BDBM50106701 |
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| Synonyms: | CHEMBL435980 | Formic acid 5,5,6a,12b-tetramethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,7,11,12,12a,12b-dodecahydro-2H-10-oxa-benzo[a]anthracen-3-yl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C27H33NO4 |
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| Mol. Mass. | 435.5552 |
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| SMILES | CC1(C)C[C@@]2(C)Cc3cc(oc(=O)c3C[C@@H]2[C@@]2(C)CC[C@@H](CC12)OC=O)-c1cccnc1 |
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| Structure | 
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