| Reaction Details |
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 | Report a problem with these data |
| Target | Ghrelin O-acyltransferase |
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| Ligand | BDBM367610 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2019849 (CHEMBL4673662) |
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| IC50 | 54±n/a nM |
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| Citation |  Iyer, MR; Wood, CM; Kunos, G Recent progress in the discovery of ghrelin RSC Med Chem11:1136-1144 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ghrelin O-acyltransferase |
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| Name: | Ghrelin O-acyltransferase |
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| Synonyms: | GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 49733.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96T53 |
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| Residue: | 435 |
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| Sequence: | MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYA
VLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITL
SSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSL
CSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFEC
IYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRIS
VFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYL
IHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVY
CILLLLLAKRKHKCN
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| BDBM367610 |
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| n/a |
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| Name | BDBM367610 |
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| Synonyms: | N-[(1S)-2-[4-[2- (4-Amino-2- chloro-6-methyl- pyrimidin-5-yl) ethyl]-1-piperidyl]-1- methyl-2-oxo-ethyl]-5- methyl-1H-pyrazole- 4-carboxamide | US10227310, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H28ClN7O2 |
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| Mol. Mass. | 433.935 |
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| SMILES | C[C@H](NC(=O)c1cn[nH]c1C)C(=O)N1CCC(CCc2c(C)nc(Cl)nc2N)CC1 |r| |
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| Structure | 
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