Ki Summary

Reaction Details

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Target

Ghrelin O-acyltransferase

Ligand

BDBM50548074

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2019857 (CHEMBL4673670)

IC50

7000±n/a nM

Citation

Iyer, MR; Wood, CM; Kunos, G Recent progress in the discovery of ghrelin RSC Med Chem11:1136-1144 (2020) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Ghrelin O-acyltransferase

Name:

Ghrelin O-acyltransferase

Synonyms:

Type:

PROTEIN

Mol. Mass.:

49896.50

Organism:

Mus musculus

Description:

ChEMBL_103545

Residue:

435

Sequence:

MDWLQLFFLHPLSFYQGAAFPFALLFNYLCILDTFSTRARYLFLLAGGGVLAFAAMGPYS
LLIFIPALCAVALVSFLSPQEVHRLTFFFQMGWQTLCHLGLHYTEYYLGEPPPVRFYITL
SSLMLLTQRVTSLSLDICEGKVEAPRRGIRSKSSFSEHLWDALPHFSYLLFFPALLGGSL
CSFRRFQACVQRSSSLYPSISFRALTWRGLQILGLECLKVALRSAVSAGAGLDDCQRLEC
IYLMWSTAWLFKLTYYSHWILDDSLLHAAGFGAEAGQGPGEEGYVPDVDIWTLETTHRIS
LFARQWNRSTALWLRRLVFRKSRRWPLLQTFAFSAWWHGLHPGQVFGFLCWSVMVKADYL
IHTFANVCIRSWPLRLLYRALTWAHTQLIIAYIMLAVEGRSLSSLCQLCCSYNSLFPVMY
GLLLFLLAERKDKRN

BDBM50548074

n/a

Name

BDBM50548074

Synonyms:

CHEMBL4750990

Type

Small organic molecule

Emp. Form.

C147H244N44O43

Mol. Mass.

3315.7793

SMILES

CCCCCCCC(=O)OC[C@H](OC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r|

Structure