Reaction Details |
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Target | Mitogen-activated protein kinase kinase kinase kinase 3 |
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Ligand | BDBM50548194 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2020700 (CHEMBL4674513) |
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IC50 | 5.0±n/a nM |
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Citation | May-Dracka, TL; Arduini, R; Bertolotti-Ciarlet, A; Bhisetti, G; Brickelmaier, M; Cahir-McFarland, E; Enyedy, I; Fontenot, JD; Hesson, T; Little, K; Lyssikatos, J; Marcotte, D; McKee, T; Murugan, P; Patterson, T; Peng, H; Rushe, M; Silvian, L; Spilker, K; Wu, P; Xin, Z; Burkly, LC Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKC? phosphorylation: Potential therapy to modulate T cell dependent immunity. Bioorg Med Chem Lett28:1964-1971 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase kinase kinase kinase 3 |
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Name: | Mitogen-activated protein kinase kinase kinase kinase 3 |
Synonyms: | M4K3_HUMAN | MAP4K3 | RAB8IPL1 |
Type: | PROTEIN |
Mol. Mass.: | 101331.91 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_586461 |
Residue: | 894 |
Sequence: | MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ
EIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRET
LQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAP
EVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM
KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDF
DDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLD
SSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDD
ESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPP
PRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTP
KVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLF
PRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKF
SVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPC
PLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVT
QLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQG
RSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY
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BDBM50548194 |
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n/a |
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Name | BDBM50548194 |
Synonyms: | CHEMBL4762312 |
Type | Small organic molecule |
Emp. Form. | C21H18Cl2FN5O |
Mol. Mass. | 446.305 |
SMILES | Nc1ncc(-c2cnn(c2)C2CCNCC2)c2cc(oc12)-c1c(Cl)ccc(F)c1Cl |
Structure |
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