| Reaction Details |
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 | Report a problem with these data |
| Target | Excitatory amino acid transporter 2 |
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| Ligand | BDBM50107948 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_68328 (CHEMBL680699) |
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| IC50 | 430000±n/a nM |
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| Citation |  Stensbøl, TB; Uhlmann, P; Morel, S; Eriksen, BL; Felding, J; Kromann, H; Hermit, MB; Greenwood, JR; Braüner-Osborne, H; Madsen, U; Junager, F; Krogsgaard-Larsen, P; Begtrup, M; Vedsø, P Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology. J Med Chem45:19-31 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Excitatory amino acid transporter 2 |
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| Name: | Excitatory amino acid transporter 2 |
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| Synonyms: | EAA2_HUMAN | EAAT2 | GLT1 | Glutamate/aspartate transporter II | SLC1A2 | Sodium-dependent glutamate/aspartate transporter 2 | Solute carrier family 1 member 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 62103.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Excitatory Amino Acid EAAT2 0 0::P43004 |
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| Residue: | 574 |
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| Sequence: | MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVC
GGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA
MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL
VQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGM
NVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKI
IAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALG
TASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVL
DGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTS
VNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYA
AHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
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| BDBM50107948 |
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| n/a |
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| Name | BDBM50107948 |
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| Synonyms: | 2-Amino-3-(2-hydroxy-2H-pyrazol-3-yl)-propionic acid | CHEMBL320290 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H9N3O3 |
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| Mol. Mass. | 171.154 |
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| SMILES | NC(Cc1ccnn1O)C(O)=O |
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| Structure | 
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