| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50108193 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_65468 |
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| IC50 | 3.1±n/a nM |
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| Citation |  Rawson, DJ; Dack, KN; Dickinson, RP; James, K The design and synthesis of a novel series of indole derived selective ET(A) antagonists. Bioorg Med Chem Lett12:125-8 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50108193 |
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| n/a |
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| Name | BDBM50108193 |
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| Synonyms: | 2-[2-Benzo[1,3]dioxol-5-yl-2-(6-carbamoyl-1-methyl-1H-indol-3-yl)-acetylsulfamoyl]-benzoic acid | CHEMBL278349 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H21N3O8S |
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| Mol. Mass. | 535.525 |
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| SMILES | Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2C(O)=O)c2ccc3OCOc3c2)c2ccc(cc12)C(N)=O |
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| Structure | 
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