Reaction Details |
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Target | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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Ligand | BDBM321865 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2023419 (CHEMBL4677232) |
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IC50 | 9.5±n/a nM |
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Citation | Thomson, CG; Le Grand, D; Dowling, M; Beattie, D; Elphick, L; Faller, M; Freeman, M; Hardaker, E; Head, V; Hemmig, R; Hill, J; Lister, A; Pascoe, D; Rieffel, S; Shrestha, B; Steward, O; Zink, F Development of autotaxin inhibitors: A series of tetrazole cinnamides. Bioorg Med Chem Lett31:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
Synonyms: | ATX | Autotaxin | Autotaxin (ATX) | E-NPP 2 | ENPP2 | ENPP2_HUMAN | Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP2) | Extracellular lysophospholipase D | LysoPLD | PDNP2 |
Type: | Enzyme |
Mol. Mass.: | 99007.13 |
Organism: | Homo sapiens (Human) |
Description: | Q13822 |
Residue: | 863 |
Sequence: | MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCK
GRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHC
SEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDA
TFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHER
PSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQH
FKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNK
VNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYG
RPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVS
PSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVL
VKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQ
PADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFR
KTSRSYPEILTLKTYLHTYESEI
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BDBM321865 |
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n/a |
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Name | BDBM321865 |
Synonyms: | (E)-1-(4-(3-Methyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-3-(2-((5-methyl-2H-tetrazol-2-yl)methyl)-4-(trifluoromethyl)phenyl)prop-2-en-1-one | US10183025, Example 2 | US9763957, Example 2 |
Type | Small organic molecule |
Emp. Form. | C21H22F3N7O2 |
Mol. Mass. | 461.4403 |
SMILES | Cc1nnn(Cc2cc(ccc2\C=C\C(=O)N2CCC(CC2)c2nc(C)no2)C(F)(F)F)n1 |
Structure |
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