Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase ULK1 |
---|
Ligand | BDBM379343 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2023820 (CHEMBL4677633) |
---|
IC50 | 40±n/a nM |
---|
Citation | Ren, H; Bakas, NA; Vamos, M; Chaikuad, A; Limpert, AS; Wimer, CD; Brun, SN; Lambert, LJ; Tautz, L; Celeridad, M; Sheffler, DJ; Knapp, S; Shaw, RJ; Cosford, NDP Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. J Med Chem63:14609-14625 (2020) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein kinase ULK1 |
---|
Name: | Serine/threonine-protein kinase ULK1 |
Synonyms: | ATG1 | Autophagy-related protein 1 homolog | KIAA0722 | ULK1 | ULK1_HUMAN | Unc-51-like kinase 1 | hATG1 |
Type: | PROTEIN |
Mol. Mass.: | 112661.80 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1510275 |
Residue: | 1050 |
Sequence: | MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL
GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ
QIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT
LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV
PTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGS
GSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV
PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGP
FSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSP
PAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSA
PEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCR
NLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRT
LPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESL
QEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAGPTG
SASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEH
TEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGFAEQL
VLYLKVAELLSSGLQSAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRF
FLDKQRLLDRIHSITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHM
LSDQADIENVTKCKLCIERRLSALLTGICA
|
|
|
BDBM379343 |
---|
n/a |
---|
Name | BDBM379343 |
Synonyms: | US10266549, Example 221a | US10774092, Example 221a |
Type | Small organic molecule |
Emp. Form. | C12H11F3N6 |
Mol. Mass. | 296.2511 |
SMILES | FC(F)(F)c1cnc(Nc2ccnnc2)nc1NC1CC1 |
Structure |
|