Reaction Details |
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Target | Tryptophan 2,3-dioxygenase |
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Ligand | BDBM50549540 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2025274 (CHEMBL4679087) |
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IC50 | 15900±n/a nM |
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Citation | Kinzel, O; Steeneck, C; Anderhub, S; Hornberger, M; Pinto, S; Morschhaeuser, B; Albers, M; Sonnek, C; Wang, Y; Mallinger, A; Czeka?ska, M; Hoffmann, T Discovery of highly potent heme-displacing IDO1 inhibitors based on a spirofused bicyclic scaffold. Bioorg Med Chem Lett33:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tryptophan 2,3-dioxygenase |
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Name: | Tryptophan 2,3-dioxygenase |
Synonyms: | T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
Type: | PROTEIN |
Mol. Mass.: | 47874.48 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_825691 |
Residue: | 406 |
Sequence: | MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
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BDBM50549540 |
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n/a |
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Name | BDBM50549540 |
Synonyms: | CHEMBL4745769 |
Type | Small organic molecule |
Emp. Form. | C25H26ClF3N2O2 |
Mol. Mass. | 478.934 |
SMILES | FC(F)(F)c1ccc2c(OCC22CCN(CC2)C(CC2CC2)C(=O)Nc2ccc(Cl)cc2)c1 |
Structure |
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