Reaction Details |
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Target | Reverse transcriptase/RNaseH |
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Ligand | BDBM50550025 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2026095 (CHEMBL4679908) |
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IC50 | 3.0±n/a nM |
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Citation | Ippolito, JA; Niu, H; Bertoletti, N; Carter, ZJ; Jin, S; Spasov, KA; Cisneros, JA; Valhondo, M; Cutrona, KJ; Anderson, KS; Jorgensen, WL Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead. ACS Med Chem Lett12:249-255 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase/RNaseH |
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Name: | Reverse transcriptase/RNaseH |
Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
Type: | PROTEIN |
Mol. Mass.: | 65229.15 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_1473730 |
Residue: | 566 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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BDBM50550025 |
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n/a |
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Name | BDBM50550025 |
Synonyms: | CHEMBL1923490 |
Type | Small organic molecule |
Emp. Form. | C21H15Cl2N3O4 |
Mol. Mass. | 444.268 |
SMILES | Clc1ccc(Oc2cc(Cl)cc(\C=C\C#N)c2)c(OCCn2ccc(=O)[nH]c2=O)c1 |
Structure |
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