| Reaction Details |
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 | Report a problem with these data |
| Target | N-lysine methyltransferase SMYD2 |
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| Ligand | BDBM50550531 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2027565 (CHEMBL4681723) |
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| IC50 | 23590±n/a nM |
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| Citation |  Cowen, SD; Russell, D; Dakin, LA; Chen, H; Larsen, NA; Godin, R; Throner, S; Zheng, X; Molina, A; Wu, J; Cheung, T; Howard, T; Garcia-Arenas, R; Keen, N; Pendleton, CS; Pietenpol, JA; Ferguson, AD Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors. J Med Chem59:11079-11097 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| N-lysine methyltransferase SMYD2 |
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| Name: | N-lysine methyltransferase SMYD2 |
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| Synonyms: | HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 49689.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NRG4 |
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| Residue: | 433 |
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| Sequence: | MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKE
GLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHP
ERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVN
CNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY
IDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARN
VIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGAL
QYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDH
PYISEIKQEIESH
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| BDBM50550531 |
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| n/a |
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| Name | BDBM50550531 |
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| Synonyms: | CHEMBL4781774 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30Cl2N4O4 |
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| Mol. Mass. | 509.425 |
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| SMILES | CN(CCNCCc1ccc(O)c2NC(=O)COc12)C(=O)CCNCCc1ccc(Cl)c(Cl)c1 |
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| Structure | 
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