| Reaction Details |
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 | Report a problem with these data |
| Target | Thromboxane-A synthase |
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| Ligand | BDBM50110454 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_210290 |
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| IC50 | >1000±n/a nM |
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| Citation |  Fujita, M; Seki, T; Inada, H; Shimizu, K; Takahama, A; Sano, T Novel agents combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI). Bioorg Med Chem Lett12:771-4 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thromboxane-A synthase |
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| Name: | Thromboxane-A synthase |
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| Synonyms: | CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 60524.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24557 |
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| Residue: | 533 |
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| Sequence: | MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
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| BDBM50110454 |
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| n/a |
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| Name | BDBM50110454 |
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| Synonyms: | 5-[(2-[1,4-dimethyl-6-(2-chloro-phenyl)-7,8,9,10-tetrahydro-4H-pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-9-yl-carbonyl]-phenyl)-pyridin-3-yl-methyleneaminooxy]-pentanoic acid ethyl ester | CHEMBL166208 |
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| Type | Small organic molecule |
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| Emp. Form. | C39H38ClN7O4S |
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| Mol. Mass. | 736.282 |
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| SMILES | CCOC(=O)CCCCO\N=C(\c1cccnc1)c1ccccc1C(=O)N1CCc2c(C1)sc-1c2C(=NC(C)c2nnc(C)n-12)c1ccccc1Cl |c:39| |
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| Structure | 
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