Reaction Details |
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Target | Genome polyprotein |
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Ligand | BDBM50111456 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_158817 (CHEMBL761626) |
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EC50 | 607±n/a nM |
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Citation | Dragovich, PS; Prins, TJ; Zhou, R; Brown, EL; Maldonado, FC; Fuhrman, SA; Zalman, LS; Tuntland, T; Lee, CA; Patick, AK; Matthews, DA; Hendrickson, TF; Kosa, MB; Liu, B; Batugo, MR; Gleeson, JP; Sakata, SK; Chen, L; Guzman, MC; Meador, JW; Ferre, RA; Worland, ST Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics. J Med Chem45:1607-23 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Genome polyprotein |
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Name: | Genome polyprotein |
Synonyms: | Human rhinovirus A protease | Human rhinovirus B 3A protease |
Type: | PROTEIN |
Mol. Mass.: | 44361.04 |
Organism: | Human rhinovirus B |
Description: | ChEMBL_158953 |
Residue: | 401 |
Sequence: | AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMS
AIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIA
NIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVIT
TGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDR
NEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYN
YPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQT
IHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA
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BDBM50111456 |
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n/a |
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Name | BDBM50111456 |
Synonyms: | 4-[2-(3-Benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-(4-fluoro-phenyl)-propionylamino]-6-carbamoyl-hex-2-enoic acid ethyl ester | CHEMBL44129 | trans-(2'S,4S)-4-[2'-(3''-Benzyloxycarbonylamino-2''-oxo-2''H-pyridin-1''-yl)-3'-(4'''-fluorophenyl)propionylamino]-6-carbamoylhex-2-enoic Acid Ethyl Ester |
Type | Small organic molecule |
Emp. Form. | C31H33FN4O7 |
Mol. Mass. | 592.6147 |
SMILES | CCOC(=O)\C=C\[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(F)cc1)n1cccc(NC(=O)OCc2ccccc2)c1=O |r| |
Structure |
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